HORDB

ID: hor001521
Uniprot ID: Q9N4V0
Protein name: DVPGVLRF-amide
Gene name: flp-18
Organism: Caenorhabditis elegans
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: Expressed in head neurons and weakly in ventral nerve cord .
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003674 molecular_function; GO:0031841 neuropeptide Y receptor binding
GO BP: GO:0006937 regulation of muscle contraction; GO:0007218 neuropeptide signaling pathway; GO:0030431 sleep
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: DVPGVLRF
Length: 8
Propeptide: MQRWSGVLLISLCCLLRGALAYTEPIYEIVEEDIPAEDIEVTRTNEKQDGRVFSKRDFDGAMPGVLRFGKRGGVWEKRESSVQKKEMPGVLRFGKRAYFDEKKSVPGVLRFGKRSYFDEKKSVPGVLRFGKRDVPMDKREIPGVLRFGKRDYMADSFDKRSEVPGVLRFGKRDVPGVLRFGKRSDLEEHYAGVLLKKSVPGVLRFGRK
Signal peptide: MQRWSGVLLISLCCLLRGALA
Modification: T8 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: FMRFamide-like neuropeptides (PubMed:14555955, PubMed:23658528). Ligand to G-protein coupled receptor npr-1 (PubMed:14555955). Involved in modulating locomotion quiescence during the sleep-like state called lethargus which occurs during molting between larval and adult stages, acting via npr-1 (PubMed:23764289). Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit (PubMed:23658528). Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001521_AF2.pdb

hor001521_ESM.pdb

Mass:	102710	Formula:	C42H67N11O11
Absent amino acids:	ACEHIKMNQSTWY	Common amino acids:	V
pI:	6.34	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	4
Hydrophobicity:	62.5	Boman Index:	-672
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	121.25
Instability Index:	5690	Extinction Coefficient cystines:	0
Absorbance 280nm:	0